Table of Contents: Oncotarget’s Volume 12, Issue #18

Read short summaries of the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 18.

Oncotarget's Table of Contents

Oncotarget’s Volume 12, Issue #18

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Cover (Priority Research Paper): Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice

Origin: Florida, United States

Institution: University of Florida 

Quote: “Aerobic exercise is receiving increased recognition in oncology for its multiple purported benefits. Exercise is known to induce physiologic adaptations that improve patient quality-of-life parameters as well as all-cause mortality. There also is a growing body of evidence that exercise may directly alter the tumor microenvironment to influence tumor growth, metastasis, and response to anticancer therapies.”

Research Paper: Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status

Origin: California, Massachusettes, United States; Levallois-Perret, France; Singapore

Institutions: University of California, Franco-British Hospital, Karyopharm Therapeutics Inc., Aide et Recherche en Cancérologie Digestive Foundation, National University of Singapore

Quote: “We examined the effects of co-treatment with selinexor and olaparib in TNBC [triple-negative breast cancer] cell lines.”

Research Paper: Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication

Origin: Maryland, United States

Institutions: University of Maryland, Institute for Genome Sciences, Veterans Affairs Medical Center

Quote: “Acute myeloid leukemia (AML) with fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) relapses with new chromosome abnormalities following chemotherapy, implicating genomic instability. Error-prone alternative non-homologous end-joining (Alt-NHEJ) DNA double-strand break (DSB) repair is upregulated in FLT3-ITD-expresssing cells, driven by c-Myc.”

Research Paper: Impact factor and citation metrics in phase III cancer trials

Origin: The University of Texas MD Anderson Cancer Center

Institution: Texas, United States

Quote: “Journal impact factor (IF) is often used to measure research quality and importance. We assessed trial factors associated with the publication of cancer trials in journals with higher IF and publications receiving higher citations.”

Research Paper: Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia

Origin: Texas, United States

Institution: Baylor College of Medicine

Quote: “Here, we showed the small molecule 5Z-7-oxozeaenol (5Z7O) induces dose-dependent cytotoxicity in a panel of T-ALL [T-cell acute lymphoblastic leukemia] cell lines mainly through inhibition of the MAP2K7-JNK pathway, which further validates MAP2K7 as a therapeutic target.”

Research Paper: Correlation between PD-L1 expression and MET gene amplification in patients with advanced non–small-cell lung cancer and no other actionable oncogenic driver

Origin: Barcelona, Spain

Institution: Germans Trias i Pujol Hospital

Quote: “Herein, we investigated the relation between MET gene amplification and PD-L1 expression in patients with advanced NSCLC [non–small-cell lung cancers] and no other actionable oncogenic driver (i.e., EGFR, ALK, ROS1).”

Research Paper: Effect of hypertension and medication use regularity on postoperative delirium after maxillofacial tumors radical surgery

Origin: Shanghai, Shandong, China

Institutions: Shanghai University of Traditional Chinese Medicine, Shanghai Jiao Tong University School of Medicine, The Second Affiliated Hospital of Shandong First Medical University

Quote: “The incidence of postoperative delirium (POD) after maxillofacial tumors radical surgery is relatively high. There are a number of evidences showing the relationship between hypertension and decreased cerebral blood flow, as well as the relationship between cerebral ischemia and postoperative cognitive impairment.”

Review: Anti-aging: senolytics or gerostatics (unconventional view)

Origin: New York, United States

Institution: Roswell Park Cancer Institute

Quote: “Senolytics are basically anti-cancer drugs, repurposed to kill senescent cells selectively. It is even more difficult to selectively kill senescent cells than to kill cancer cells. Based on lessons of cancer therapy, here I suggest how to exploit oncogene-addiction and to combine drugs to achieve selectivity.”

Case Report: The value of comprehensive genomic sequencing to maximize the identification of clinically actionable alterations in advanced cancer patients: a case series

Origin: Arizona, United States

Institutions: Translational Genomic Research Institute, Ashion Analytics, LLC, HonorHealth Research Institute

Quote: “We present seven cases of advanced cancer patients who initially underwent tumor testing utilizing smaller, panel-based tests, followed by a variety of therapeutic treatments which ultimately resulted in progression of their disease.”

Juvenile polyposis without a germline variant in SMAD4/BMPR1A: defining a clinically distinct polyposis syndrome

Origin: Philadelphia, United States

Institutions: The Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine

Quote: “Juvenile Polyposis Syndrome (JPS) is a rare gastrointestinal (GI) polyposis syndrome in which
approximately half of cases are caused by constitutional changes in SMAD4 or BMPR1A. The other half of JPS cases lack a known genetic driver (i.e., mutation-negative) and are instead diagnosed clinically based on existing criteria including having five or greater pathologically defined juvenile polyps in the lower GI tract, juvenile polyps in the upper and lower GI tract, or any number of juvenile polyps with a family history of JPS.”

Research Perspective: 
Targeting cancer stem cells via integrin β4

Origin: Michigan, United States; Wuhan, China

Institutions: University of Michigan, Renmin Hospital of Wuhan University

Quote: “Integrins mediate cell-cell interactions and communication with the extracellular matrix (ECM). These transmembrane protein receptors allow binding between a cell and its surroundings, initiating a breadth of intracellular signaling resulting in proliferation, differentiation, survival, or migration. Such responses have made integrins an attractive target for cancer therapy.”

Click here to read Oncotarget’s Volume 12, Issue #18.

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