Table of Contents: Oncotarget’s Volume 12, Issue #11

Read short summaries of the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 11.

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Oncotarget’s Volume 12, Issue #11

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New Publications

Cover (Research Paper): CEA as a blood-based biomarker in anal cancer

Origin: Texas, California, Tennessee, United States

Institutions: The University of Texas – MD Anderson Cancer Center, Terasaki Foundation of Biomedical Sciences, Vanderbilt Ingram Cancer Center

Quote: “The clinical utility of a blood-based biomarker in squamous cell carcinoma of the anus (SCCA) is unknown. We analyzed carcinoembryonic antigen (CEA), a commonly employed assay for patients with colorectal adenocarcinoma, as a serum biomarker for patients with biopsy-proven SCCA.”

News: FGFR1, a novel biomarker for metastatic castration-resistant prostate cancer?

Origin: Florida, United States

Institution: The Scripps Research Institute

Quote: “Prostate cancer is the second most common cause of cancer-related death among men in the United States [1]. In a seminal paper eighty years ago, Huggins and Hodges demonstrated that prostate tumors and metastatic disease are sensitive to the presence or absence of androgenic hormones [2].”

Editorial Paper: Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response

Origin: California, United States

Institution: Stanford University

Quote: “The advent of advanced exosome purification methods has made it possible to tap on the unexplored potential of these tiny particles in clinically-precise diagnosis and treatment of a myriad of diseases [6–8].”

Editorial Paper: Drug-development, dose-selection, rational combinations from bench-to-bedside: are there any lessons worth revisiting?

Origin: Michigan, United States

Institutions: University of Michigan

Quote: “The development of a new treatment modality, especially a novel cancer drug, is arduous work and takes years from conception to apparent success (or failure). The process for new drug approval is prolonged, taking 5–15 years with billions of dollars of investment.”

Research Paper: Occurence of RAS reversion in metastatic colorectal cancer patients treated with bevacizumab

Origin: Locarno, Bellinzona, Switzerland; Novara, Legnano, Italy

Institutions: Ente Ospedaliero Cantonale, University of Eastern Piedmont, Ospedale di Legnano

Quote: “A disappearance of RAS mutations in the plasma of about 50% of mCRCs (metastatic colorectal cancers) treated with bevacizumab-based chemotherapy has been reported. Our aim was to evaluate the same issue at tissue level.”

Research Paper: Caspase-11 and AIM2 inflammasome are involved in smoking-induced COPD and lung adenocarcinoma

Origin: Salerno, Naples, Italy; Munich, Germany; Patras, Greece

Institutions: University of Salerno, Ludwig-Maximilians University and Helmholtz Center, University of Patras, University of Naples

Quote: “To mimic COPD, we exposed mice to nose-only cigarette smoke and used human samples of lung adenocarcinoma patients according to the smoking and COPD status.”

Research Paper: A novel E2F1-regulated lncRNA, LAPAS1, is required for S phase progression and cell proliferation

Origin: Ramat Gan, Safed, Israel

Institutions: Bar-Ilan University

Quote: “Increasing evidence indicates that lncRNAs are key regulators of important biological processes including cell cycle progression [5], cell proliferation and apoptosis [6]. Specifically, some lncRNAs function in regulation of cell cycle progression via modulation of critical cell cycle players, such as the cyclins, CDKs, CDK inhibitors, pRB, and p53 [5, 7–9].”

Research Paper: Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network

Origin: Pune 411008, Ghaziabad 201002, India

Institutions: CSIR-National Chemical Laboratory, Academy of Scientific and Innovative Research

Quote: “Alzheimer’s disease is a type of dementia denoted by progressive neuronal death due to the accumulation of proteinaceous aggregates of Tau. Post-translational modifications like hyperphosphorylation, truncation, glycation, etc. play a pivotal role in Tau pathogenesis.”

Research Paper: Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma

Origin: Turku, Helsinki, Finland; Sheffield, United Kingdom; Patras, Greece; Stockholm, Sweden

Institutions: Misvik Biology Oy, University of Sheffield, University of Patras, Karolinska Institutet, Docrates Cancer Hospital 

Quote: “Cutaneous apocrine carcinoma is an extreme rare malignancy derived from a sweat gland. Histologically sweat gland cancers resemble metastatic mammary apocrine carcinomas, but the genetic landscape remains poorly understood. Here, we report a rare metastatic case with a PALB2 aberration identified previously as a familial susceptibility gene for breast cancer in the Finnish population.”

Review Paper: Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment

Origin: Louisiana, North Carolina, United States

Institutions: Tulane University School of Medicine, LSUHSC School of Medicine, University of North Carolina

Quote: “LKB1-signaling has prominent roles in cancer development and metastasis. This report evaluates LKB1-signaling pathway gene expression associations with patient survival in overall breast cancer, specific subtypes, as well as pre- and post-chemotherapy.”

Case Report: Immunotherapy in Xeroderma Pigmentosum: a case of advanced cutaneous squamous cell carcinoma treated with cemiplimab and a literature review

Origin: Turin, Pavia, Italy

Institutions: University of Turin, National Center of Oncological Hadrontherapy

Quote: “Xeroderma Pigmentosum (XP) is a rare genetic disorder with a poor prognosis due to high photosensitivity in affected patients. Herein, we describe the first case of the use of cemiplimab in a patient with XP, a 19-year-old girl presented with locally advanced squamous cell carcinoma of the right periorbital and nasal region. This treatment has been undertaken after a cycle of proton beam radiotherapy.”

Click here to read Oncotarget’s Volume 12, Issue #11.

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Oncotarget is a proud exhibitor and sponsor of the SSP Annual Meeting
Oncotarget is a proud exhibitor and sponsor of the SSP Annual Meeting

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