Table of Contents: Oncotarget’s Volume 12, Issue #4

Read short summaries of the latest research literature published by Oncotarget.

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Oncotarget’s Volume 12, Issue #4

New Publications


Cover (Research Paper): Phase 1 study of Z-Endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors

Origin: Maryland, Minnesota, Oregon, United States

Institutions: National Cancer Institute, National Eye Institute, Mayo Clinic, Rochester, Frederick National Laboratory for Cancer Research, Oregon Health & Science University

Quote: “Administration of Z-endoxifen was well tolerated, but resulted in an adverse event profile distinct from that observed with tamoxifen at higher plasma levels of the active metabolite.”


Editorial Paper: Data driven precision medicine: who is the driver?

Origin: Münster, Germany

Institution: University Hospital Münster

Quote: “While the accumulation of data appears fundamentally important, the careful examination and even more evidently, integration and interpretation of these results is key.”


Research Paper: Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells

Origin: Texas, United States

Institution: Baylor College of Medicine Houston, Texas Children’s Hospital

Quote: “Here, we found expression of the transcription factor KLF4 in AML cell lines is not silenced through KLF4 gene methylation nor via proteasomal degradation.”


Research Paper: Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer

Origin: Missouri, North Carolina, United States

Institutions: Washington University School of Medicine, University of North Carolina School of Medicine

Quote: “Given the interplay between Reg4 and colorectal cancer aggressiveness, we sought to investigate if expression of Reg4 and its downstream proteins are associated with clinical recurrence and overall survival in stage II and III colorectal cancer patients treated with curative intent.”


Research Paper: Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-Cell mediated anti-tumor immunity in an esophageal adenocarcinoma model

Origin: Pennsylvania, Texas, California, United States

Institution: Allegheny Health Network, Baylor University Medical Center, Beckman Research Institute of City of Hope

Quote: “STING is a transmembrane protein that activates transcription of interferon genes, resulting in stimulation of APCs and enhanced CD8+ T-cell infiltration. The present study evaluates STING agonists, alone and in combination with radiation to determine durable anticancer activity in solid tumors.”


Research Paper: Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration

Origin: Marseille, France

Institution: Institute of NeuroPhysiopathology, Hôpital de la Timone

Quote: “Here, we thus investigated the non-histone dependent effects of low doses of vorinostat on GBM cells behaviors and on microtubular system.”


Research Paper: Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach

Origin: Badalona, Barcelona, Madrid, Spain

Institution: Hospital Germans Trias i Pujol, Takeda Farmacéutica España, Anaxomics Biotech, Universitat Pompeu Fabra

Quote: “In the present study, we compare the potential differences between brigatinib and alectinib’s mechanisms of action as first-line treatment for ALK+ NSCLC in a systems biology-based in silico setting.”


Research Paper: The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma

Origin: Tokushima, Japan

Institution: Tokushima University Graduate School

Quote: “Therefore, this study particularly focused on the direct relationship between CAFs and TAMs in HCC. We showed that TAMs activated hepatic stellate cells, which promoted cancer proliferation and migration. Additionally, we identified osteopontin (OPN) as a key molecule involved in cancer-CAF-TAM interactions in HCC.”


Research Paper: Oncolytic virotherapy with SOCS3 enhances viral replicative potency and oncolysis for gastric cancer

Origin: Wakayama, Tokyo, Osaka, Japan

Institution: Wakayama Medical University, Wakayama Medical University, The University of Tokyo, Osaka Minami Medical Center

Quote: “Here, we focus on SOCS3 for oncolytic virotherapy using HSV for gastric cancer. We generated a new type of oHSVs expressing SOCS-3 (T-SOCS3) and compared with the third-generation type of oncolytic HSV (T-01) with T-SOCS3 in viral replication potency and the oncolytic effect.”


Research Paper: Quercetin shortened survival of radio-resistant B-1 cells in vitro and in vivo by restoring miR15a/16 expression

Origin: São Paulo, Brazil

Institution: Universidade Federal de São Paulo

Quote: “Herein, radioresistant B-1 cells were treated with quercetin in vitro, which reduces cell survival and proliferation. This study aimed to determine if quercetin could block the anti-apoptotic profile of radioresistant B-1 cells by interfering in miRNA levels and Bcl-2.”


Research Paper: Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2

Origin: Shanghai, China

Institution: Second Military Medical University

Quote: “In conclusion, our studies disclosed the chemopreventive effect of FA supplementation on hepatocarcinogenesis, which partial attributed to the inhibition of LCN2 by regulating histone methylation in promoter. Our results provide a potential mechanism of the chemoprevention of FA supplementation on tumorigenesis of HCC and may be helpful in developing treatment target against HCC.”


Research Review: Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers

Origin: Tennessee, United States, Lviv, Ukraine

Institution: South College, Vanderbilt University Medical Center, Danylo Halytsky Lviv National Medical University

Quote: “This review article summarizes an up-to-date body of information from published studies on CYP enzymes expression levels and pathophysiological functions in human normal and malignant gastrointestinal (GI) tract tissues.”


Click here to read Oncotarget’s Volume 12, Issue #4.

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