Table of Contents: Oncotarget’s Volume 12, Issue #3

Read a short summary of the latest research literature published by Oncotarget.

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Oncotarget’s Volume 12, Issue #3

New Publications

Cover Paper (Research Perspective): The goal of geroscience is life extension

Origin: New York, United States

Institutions: Roswell Park Cancer Institute

Quote: “Although numerous drugs seemingly extend healthspan in mice, only a few extend lifespan in mice and only one does it consistently. Some of them, alone or in combination, can be used in humans, without further clinical trials.

Research Paper: High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma

Origin: Maryland, Washington D.C., United States

Institution: Uniformed Services University, Georgetown University Medical Center, The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Quote: “In this report, we analyzed the mRNA expression profile of 30 LY6 genes located on chromosomes 6, 8, 11 and 19 using the public The Cancer Genome Atlas (TCGA) dataset of 177 PDAC patients and their association with overall survival outcome.”

Research Paper: Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma

Origin: Maryland, Michigan, United States

Institution: National Institutes of Health, University of Michigan

Quote: “Here we show that ubiquitin-specific peptidase 9, X-linked (Usp9x), a deubiquitinase (DUB) enzyme controls SOX2 levels in melanoma.”

Research Paper: A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells

Origin: California, United States, Jiangsu, China, Saitama, Japan

Institutions: University of California, Model Animal Research Center of Nanjing University, Saitama Medical University, Lawrence Berkeley National Laboratory

Quote: “In summary, this study indicates that HIPK2 isoform 3, the main HIPK2 isoform expressed in NSCLC, promotes YAP/TEAD transcriptional activity in NSCLC cells. Our results suggest that HIPK2 isoform 3 may be a potential therapeutic target for NSCLC.”

Research Paper: MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs

Origin: Michigan, United States

Institution: Henry Ford Hospital, Oakland University, Wayne State University, University of Michigan–Dearborn

Quote: “In conclusion, the present in vitro study provides evidence that hCEC-Exo-214 significantly enhances the anti-tumor efficacy of oxaliplatin and sorafenib on HCC cells.”

Research Paper: Testosterone deficiency in men receiving immunotherapy for malignant melanoma

Origin: Iowa, United States

Institution: University of Iowa

Quote: “We performed retrospective chart review of patients with malignant melanoma treated with immunotherapy. Low testosterone was identified in 34 out of 49 patients at some point during their treatment with immunotherapy.”

Research Paper: Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors

Origin: Quebec, Canada

Institution: Quebec Heart and Lung Institute Research Center, Laval University

Quote: “Overall, our findings delineated the degree of benefit of the two proliferation markers, and offers new layer to predict the biological behavior and identify high-risk patients using a more comprehensive diagnostic workup.”

Research Paper: Folinic acid in colorectal cancer: esquire or fellow knight? Real-world results from a mono institutional, retrospective study

Origin: Naples, Italy

Institution: Antonio Cardarelli Hospital, Federico II University, Antonio Cardarelli Hospital

Quote: “Our retrospective, single-center observational study is the first with the aim of evaluating differences between these administration modalities: in particular, we wondered if co-administration of 5FU and folinic acid in continuous infusion was as effective as the classic sequential administration, or even more effective in terms of progression free- and overall survival, especially considering the aforementioned preclinical data.”

Review: Cancer stem cells and macrophages: molecular connections and future perspectives against cancer

Origin: Modena, Italy, AlQaseem, Saudi Arabia

Institution: University of Modena and Reggio Emilia, Sulaiman AlRajhi Medical School

Quote: “The aim of this review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies.”

Click here to read Oncotarget’s Volume 12, Issue #3.

Oncotarget is a unique platform designed to house scientific studies in a journal format that is available for anyone to read—without a paywall making access more difficult. This means information that has the potential to benefit our societies from the inside out can be shared with friends, neighbors, colleagues, and other researchers, far and wide.

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