Read a short summary of the latest research literature published by Oncotarget.
Oncotarget’s Volume 12, Issue #3
Cover Paper (Research Perspective): The goal of geroscience is life extension
Origin: New York, United States
Institutions: Roswell Park Cancer Institute
Quote: “Although numerous drugs seemingly extend healthspan in mice, only a few extend lifespan in mice and only one does it consistently. Some of them, alone or in combination, can be used in humans, without further clinical trials.“
Research Paper: High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma
Origin: Maryland, Washington D.C., United States
Institution: Uniformed Services University, Georgetown University Medical Center, The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.
Quote: “In this report, we analyzed the mRNA expression profile of 30 LY6 genes located on chromosomes 6, 8, 11 and 19 using the public The Cancer Genome Atlas (TCGA) dataset of 177 PDAC patients and their association with overall survival outcome.”
Origin: Maryland, Michigan, United States
Institution: National Institutes of Health, University of Michigan
Quote: “Here we show that ubiquitin-specific peptidase 9, X-linked (Usp9x), a deubiquitinase (DUB) enzyme controls SOX2 levels in melanoma.”
Research Paper: A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells
Origin: California, United States, Jiangsu, China, Saitama, Japan
Institutions: University of California, Model Animal Research Center of Nanjing University, Saitama Medical University, Lawrence Berkeley National Laboratory
Quote: “In summary, this study indicates that HIPK2 isoform 3, the main HIPK2 isoform expressed in NSCLC, promotes YAP/TEAD transcriptional activity in NSCLC cells. Our results suggest that HIPK2 isoform 3 may be a potential therapeutic target for NSCLC.”
Research Paper: MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs
Origin: Michigan, United States
Institution: Henry Ford Hospital, Oakland University, Wayne State University, University of Michigan–Dearborn
Quote: “In conclusion, the present in vitro study provides evidence that hCEC-Exo-214 significantly enhances the anti-tumor efficacy of oxaliplatin and sorafenib on HCC cells.”
Origin: Iowa, United States
Institution: University of Iowa
Quote: “We performed retrospective chart review of patients with malignant melanoma treated with immunotherapy. Low testosterone was identified in 34 out of 49 patients at some point during their treatment with immunotherapy.”
Research Paper: Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors
Origin: Quebec, Canada
Institution: Quebec Heart and Lung Institute Research Center, Laval University
Quote: “Overall, our findings delineated the degree of benefit of the two proliferation markers, and offers new layer to predict the biological behavior and identify high-risk patients using a more comprehensive diagnostic workup.”
Research Paper: Folinic acid in colorectal cancer: esquire or fellow knight? Real-world results from a mono institutional, retrospective study
Origin: Naples, Italy
Institution: Antonio Cardarelli Hospital, Federico II University, Antonio Cardarelli Hospital
Quote: “Our retrospective, single-center observational study is the first with the aim of evaluating differences between these administration modalities: in particular, we wondered if co-administration of 5FU and folinic acid in continuous infusion was as effective as the classic sequential administration, or even more effective in terms of progression free- and overall survival, especially considering the aforementioned preclinical data.”
Review: Cancer stem cells and macrophages: molecular connections and future perspectives against cancer
Origin: Modena, Italy, AlQaseem, Saudi Arabia
Institution: University of Modena and Reggio Emilia, Sulaiman AlRajhi Medical School
Quote: “The aim of this review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies.”
Click here to read Oncotarget’s Volume 12, Issue #3.
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