Tagged: NSCLC

Lung Cancer Diagram: Microscopic View of Diseased Lung Tissue - Medical Illustration

New Insights into HER2-Mutated Non-Small Cell Lung Cancer in Brazil

In non–small cell lung cancer (NSCLC), alterations in the HER2 (ERBB2) gene define a... read more

October 8, 2025

Monoclonal antibodies are used to treat lung cancer. They are created in a lab and designed to target specific proteins on cancer cells, stopping them from growing and dividing.

Amivantamab Monotherapy in Rare EGFR-Mutated Advanced NSCLC

Amivantamab, an anti-EGFR/MET bispecific antibody, shows efficacy in EGFR-mutated NSCLC, but its role in... read more

August 26, 2025

Lung cancer

A Rare Genetic Shift That Helped Lung Cancer Evade Treatment

This case adds to the literature on bypass signaling as a mechanism of resistance to... read more

March 12, 2025

New ideas

Trending With Impact: Unconventional Method Effectively Targets NSCLC

In a trending paper published by Oncotarget, researchers developed a divergent strategy to treat non-small... read more

September 30, 2021

Figure 2: Overview of brigatinib’s and alectinib’s mechanisms of action. Receptor targets of each drug are depicted through the cell membrane and the following pathways and pathophysiological motives affected are depicted from the cell surface to the nucleus. Alectinib acts through ALK and RET, involved mainly in survival and proliferation, while brigatinib acts also through ALK and FLT3, IGF1R, and EGFR, signaling through overlapping intracellular mechanisms affecting cell survival and proliferation, metastasis, apoptosis and migration. Bibliographical validation information of interactions on the predicted mechanisms of action are shown in Supplementary data (Supplementary Table 1).

Trending with Impact: Machine Learning Used to Compare ALK Inhibitors

Researchers use a computer simulated modeling system to highlight the strengths and weaknesses of two... read more

March 4, 2021

Photomicrograph of fine needle aspiration (FNA) cytology of a pulmonary (lung) nodule showing adenocarcinoma, a type of non small cell carcinoma.

Trending with Impact: Novel MicroRNA Underexpressed in Lung Cancer

In search of new ways to target lung cancer cells, researchers in this study demonstrated... read more

February 4, 2021