Read short summaries of the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 10.
Oncotarget’s Volume 12, Issue #10
Cover (Research Paper): Inhibitory effects of Tomivosertib in acute myeloid leukemia
Origin: Illinois, United States
Institutions: Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Jesse Brown Veterans Affairs Medical Center
Quote: “The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for acute myeloid leukemia (AML). We evaluated the therapeutic potential of the highly-selective MNK1/2 inhibitor Tomivosertib on AML cells.”
Editorial Paper: Raman spectroscopy determination of the mineral characteristics of microcalcifications in breast cancer, a way towards an improved screening approach
Origin: Milano, Italy
Institution: Università di Milano
Quote: “Raman Spectroscopy (RS) is a photonic approach that allows a label-free characterization of mineral samples in real-time and virtually without the need to use any sample preparation protocol .”
Editorial Paper: Reactive oxygen species in leukemias: maintaining cancer cell proliferation via redox signaling and changing metabolic homeostasis
Origin: Wales, United Kingdom
Institution: Cardiff University
Quote: “Indeed, revelations of novel insights into pathways that lead to the survival and proliferation of AML [acute myeloid leukemia] cells is opening new therapeutic possibilities [5, 6]. One such possible pathway includes reprogramming metabolism. A recent report by our group, Robinson et al., 2020, showed that reactive oxygen species (ROS) which are inappropriately produced by NAPDH oxidase (NOX2) on the surface of AML cells, can alter AML cell metabolism to support proliferation .”
Research Paper: Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cells
Origin: Indiana, Wisconsin, United States
Institutions: University of Wisconsin-Madison, Indiana University School of Medicine
Quote: “In this clinical corelative study, we found that Glioblastoma (GBM) induces multi- and mixed-lineage immune response in the tumor microenvironment. Whole-genome bisulfite sequencing of tumor infiltrating and blood CD4+ T-cell from GBM patients showed 13571 differentially methylated regions and a distinct methylation pattern of methylation of tumor infiltrating CD4+ T-cells with significant inter-patient variability.”
Research Paper: Association between miRNA signatures in serum samples from epidermal growth factor inhibitor treated patients and skin toxicity
Origin: Bonn, Aachen, Ulm, Munich, Kempten, Germany
Institutions: Federal Institute for Drugs and Medical Devices, Center for Allergy Research and Education, Hospital Group Allgäu, Medical Centre for Haematology and Oncology, University of Ulm, Ludwig-Maximilians-University of Munich, University Hospital of the RWTH Aachen
Quote: “In our study, we searched for associations of miRNA expression profiles in serum, with the severity of skin rash, in order to identify tentative therapy predictive biomarkers.”
Research Paper: Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery
Origin: Heidelberg, Germany
Institutions: Heidelberg University Hospital, German Cancer Research Center, German Cancer Consortium, University of Heidelberg
Quote: “Modern anesthesia strives to offer personalized concepts to meet the patient’s individual needs in sight of clinical outcome. Still, little is known about the impact of anesthesia on the plasma metabolome, although many metabolites have been shown to modulate the function of various immune cells, making it particularly interesting in the context of oncological surgery. In this study longitudinal dynamics in the plasma metabolome during general anesthesia in patients undergoing pancreatic surgery were analyzed.”
Research Paper: Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection
Origin: Lübeck, Ploen, Germany
Institutions: Universität zu Lübeck and UKSH, Max-Planck-Institute for Evolutionary Biology
Quote: “Here we describe a systematic deep transcriptome analysis of representative pools of urine RNA collected from healthy donors versus bladder cancer patients according to established SOPs.”
Click here to read Oncotarget’s Volume 12, Issue #10.
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