Table of Contents: Oncotarget’s Volume 12, Issue #2

Read short summaries of the latest oncology-focused peer-reviewed literature published bi-weekly by Oncotarget.

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Oncotarget’s Volume 12, Issue #2

New Publications


Cover Paper: Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma

Origin: New York, United States

Institutions: Columbia University

Quote: “We postulate that combining anti-tumor antibodies with standard-of-care strategies such as immune checkpoint blockade or targeted therapy, will improve therapeutic outcomes in cancer.”


Research Perspective: Clinical application of liquid biopsies to detect somatic BRCA1/2 mutations and guide potential therapeutic intervention for patients with metastatic breast cancer

Origin: Massachusetts, United States

Institution: Harvard Medical School

Quote: “In this article, we discuss recent studies using cell-free DNA testing to identify and classify somatic BRCA1/2 mutations in metastatic breast cancer, and potential future applications for the treatment of metastatic breast cancer.


Research Paper: A priori prediction of response in multicentre locally advanced breast cancer (LABC) patients using quantitative ultrasound and derivative texture methods

Origin: Ontario, Canada; Texas, United States

Institution: Sunnybrook Health Sciences Centre, University of Toronto, Sunnybrook Research Institute, University Health Network, Western University, Ryerson University, University of Texas

Quote: “We develop a multi-centric response predictive model using QUS spectral parametric imaging and novel texture-derivate methods for determining tumour responses to neoadjuvant chemotherapy (NAC) prior to therapy initiation.


Research Paper: Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I–III breast cancer: Multicenter study

Origin: Hyogo, Maebashi, Osaka, Tokyo, Japan

Institutions: Hyogo College of Medicine, Nippon Medical School Hospital, National Cancer Center Hospital, Kinki University Faculty of Medicine, Gunma Prefectural College of Health Sciences

Quote: “This study investigated harmonized pretreatment volume-based quantitative FDG-PET/CT parameters in breast cancer patients for prognostic value.


ReviewReversing oncogenic transformation with iron chelation

Origin: Newcastle upon Tyne, United Kingdom

Institution: Northumbria University

Quote: “This review will evaluate the impact of iron chelation on cancer cell survival and the underlying mechanisms of action.”


Case Report: Standardized diagnostic algorithm for spitzoid lesions aids clinical decision-making and management: a case series from a Swiss reference center

Origin: Zurich, Switzerland

Institution: University Hospital Zurich, Children’s Hospital Zurich

Quote: “We illustrate how clinical, histological and molecular features contribute to an optimized management plan in these critical situations and present a possible algorithm for the assessment of spitzoid neoplasms.


Click here to read Oncotarget’s Volume 12, Issue #2.

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