Read short summaries every other week on the latest oncology focused peer-reviewed literature published by Oncotarget.
Oncotarget’s Volume 11, Issue #52
Cover Paper: Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma
Origin: Tokushima, Beppu, Kumamoto, Japan
Institutions: Tokushima University Graduate School, Kyushu University Beppu Hospital, Kumamoto University
Summary: Researchers further evaluate the clinical significance of TBX15 expression levels associated with tumor phenotype in heptocellular carcinoma (HCC) as well as with the prognosis of patients with HCC who underwent hepatectomy.
Research Paper: Damage-associated molecular pattern (DAMP) activation in melanoma: investigation of the immunogenic activity of 15-deoxy, Δ12,14 prostamide J2
Origin: North Carolina, United States
Institution: East Carolina University
Summary: This study investigates whether 15dPMJ2 induces damage-associated molecular pattern (DAMP) signaling in metastatic melanoma.
Research Paper: Gastrointestinal stromal tumors (GISTs) and synchronous intra-abdominal malignancies: case series of a single institution’s experience
Origin: Thessaly, Crete, Larissa, Greece
Institutions: University Hospital of Larisa, University of Crete, University of Thessaly, Mezourlo
Summary: Researchers conduct a retrospective study using medical and pathological records from 69 patients who underwent surgical treatment for gastrointestinal stromal tumors in a single university surgical department between 2011 and 2019.
Research Paper: Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma
Origin: Buenos Aires Province, Argentina and Lund, Sweden
Institutions: Quilmes National University, Lund University
Summary: This study demonstrates high expression of terminal SLex associated with high-grade glioma, as part of complex N-glycans with β1,6-GlcNAc branching, and the potential involvement of histone acetylation in the resulting glycophenotype. Furthermore, this study stresses the role of sialylated and fucosylated complex N-glycans in the malignant behavior of high-grade glioma cells.
Case Report: Successful administration of sequential TVEC and pembrolizumab followed by Temozolomide in immunotherapy refractory intracranial metastatic melanoma with acquired B2M mutation
Origin: Missouri, United States
Institution: Washington University School of Medicine
Summary: This paper is a case report of a patient with immunotherapy refractory intracranial metastatic melanoma after initial response to ICI who had acquired B2M mutation.
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